Sycamore Creek Ranch is located in the beautiful hills of Southeastern Ohio in the small town of Londonderry. If you are looking for an extra-large family companion you have come to the right place. To be considered for an American Mastiff puppy from our ranch, you must agree to early socialization and ongoing obedience training. Your puppy must live in your home as a member of your family. You must also agree to have your puppy spayed/neutered.